Utilization and SLO-Based Control for Dynamic Sizing of Resource Partitions”,

Abstract. This paper deals with a shared server environment where the server is divided into a number of resource partitions and used to host multiple applications at the same time. In a case study where the HP-UX Process Resource Manager is taken as the server partitioning technology, we investigate the technical challenges in performing automated sizing of a resource partition using a feedback control approach, where the CPU entitlement for the partition is dynamically tuned to regulate output metrics such as the CPU utilization or SLO-based application performance metric. We identify the nonlinear and bimodal properties of the models across different operating regions, and discuss their implications for the design of the control loops. To deal with these challenges, we then propose two adaptive controllers for tracking the target utilization and target response time respectively. We evaluate the performance of the closed-loop systems while varying certain operating conditions. We demonstrate that better performance and robustness can be achieved with these controllers compared with other controllers or our prior solution

DINOMO: An Elastic, Scalable, High-Performance Key-Value Store for Disaggregated Persistent Memory (Extended Version)

We present Dinomo, a novel key-value store for disaggregated persistent memory (DPM). Dinomo is the first key-value store for DPM that simultaneously achieves high common-case performance, scalability, and lightweight online reconfiguration. We observe that previously proposed key-value stores for DPM had architectural limitations that prevent them from achieving all three goals simultaneously. Dinomo uses a novel combination of techniques such as ownership partitioning, disaggregated adaptive caching, selective replication, and lock-free and log-free indexing to achieve these goals. Compared to a state-of-the-art DPM key-value store, Dinomo achieves at least 3.8x better throughput on various workloads at scale and higher scalability, while providing fast reconfiguration.Comment: This is an extended version of the full paper to appear in PVLDB 15.13 (VLDB 2023

RLIP76, a non-ABC transporter, and drug resistance in epilepsy

BACKGROUND: Permeability of the blood-brain barrier is one of the factors determining the bioavailability of therapeutic drugs and resistance to chemically different antiepileptic drugs is a consequence of decreased intracerebral accumulation. The ABC transporters, particularly P-glycoprotein, are known to play a role in antiepileptic drug extrusion, but are not by themselves sufficient to fully explain the phenomenon of drug-resistant epilepsy. Proteomic analyses of membrane protein differentially expressed in epileptic foci brain tissue revealed the frequently increased expression of RLIP76/RALBP1, a recently described non-ABC multi-specific transporter. Because of a significant overlap in substrates between P-glycoprotein and RLIP76, present studies were carried out to determine the potential role of RLIP76 in AED transport in the brain. RESULTS: RLIP76 was expressed in brain tissue, preferentially in the lumenal surface of endothelial cell membranes. The expression was most prominent in blood brain barrier tissue from excised epileptic foci. Saturable, energy-dependent, anti-gradient transport of both phenytoin and carbamazepine were demonstrated using recombinant RLIP76 reconstituted into artificial membrane liposomes. Immunotitration studies of transport activity in crude membrane vesicles prepared from whole-brain tissue endothelium showed that RLIP76 represented the dominant transport mechanism for both drugs. RLIP76(-/- )knockout mice exhibited dramatic toxicity upon phenytoin administration due to decreased drug extrusion mechanisms at the blood-brain barrier. CONCLUSION: We conclude that RLIP76 is the predominant transporter of AED in the blood brain barrier, and that it may be a transporter involved in mechanisms of drug-resistant epilepsy

RLIP76, a Glutathione-Conjugate Transporter, Plays a Major Role in the Pathogenesis of Metabolic Syndrome

PURPOSE: Characteristic hypoglycemia, hypotriglyceridemia, hypocholesterolemia, lower body mass, and fat as well as pronounced insulin-sensitivity of RLIP76⁻/⁻ mice suggested to us the possibility that elevation of RLIP76 in response to stress could itself elicit metabolic syndrome (MSy). Indeed, if it were required for MSy, drugs used to treat MSy should have no effect on RLIP76⁻/⁻ mice. RESEARCH DESIGN AND METHODS: Blood glucose (BG) and lipid measurements were performed in RLIP76⁺/⁺ and RLIP76⁻/⁻ mice, using Ascensia Elite Glucometer® for glucose and ID Labs kits for cholesterol and triglycerides assays. The ultimate effectors of gluconeogenesis are the three enzymes: PEPCK, F-1,6-BPase, and G6Pase, and their expression is regulated by PPARγ and AMPK. The activity of these enzymes was tested by protocols standardized by us. Expressions of RLIP76, PPARα, PPARγ, HMGCR, pJNK, pAkt, and AMPK were performed by Western-blot and tissue staining. RESULTS: The concomitant activation of AMPK and PPARγ by inhibiting transport activity of RLIP76, despite inhibited activity of key glucocorticoid-regulated hepatic gluconeogenic enzymes like PEPCK, G6Pase and F-1,6-BP in RLIP76⁻/⁻ mice, is a salient finding of our studies. The decrease in RLIP76 protein expression by rosiglitazone and metformin is associated with an up-regulation of PPARγ and AMPK. CONCLUSIONS/SIGNIFICANCE: All four drugs, rosiglitazone, metformin, gemfibrozil and atorvastatin failed to affect glucose and lipid metabolism in RLIP76⁻/⁻ mice. Studies confirmed a model in which RLIP76 plays a central role in the pathogenesis of MSy and RLIP76 loss causes profound and global alterations of MSy signaling functions. RLIP76 is a novel target for single-molecule therapeutics for metabolic syndrome

Developing Information Technology Solutions in Indian Languages: Pros and Cons

A very large part of the content in our country is in various local languages. Language is a barrier to get the full advantage of this knowledge. In order to remove the language barrier, computer and IT solutions can play a major role. It is needed to create a system of multilingual content knowledge base so that it can serve all-regional community requirements. However this is not an easy task as there are various technological hurdles and lack of commitment. Commercial companies are not interested in developing such solutions, as there is no such big market in doing that. This paper gives an insight about developing the local language solutions and it’s pros and cons. It also discusses about the initiatives taken by the government and its supported organisatons